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Related Experiment Video

Updated: Apr 11, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Four-Repeat Tauopathy With PSP-Like Features in Severe Intellectual Disability: Two Autopsy Cases.

Yukiko Hata1, Hiroya Kaneko2, Koji Yoshida1

  • 1Department of Legal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan.

Neuropathology and Applied Neurobiology
|April 9, 2026
PubMed
Summary
This summary is machine-generated.

Lifelong severe intellectual disability in two adults was linked to four-repeat tauopathy. This suggests primary tau pathology may affect individuals with intellectual disability, expanding understanding of brain conditions.

Area of Science:

  • Neuropathology
  • Neurogenetics
  • Intellectual Disability Research

Background:

  • Lifelong severe intellectual disability (ID) is often associated with various neuropathological findings.
Keywords:
autopsyfour‐repeat tauopathymolecular autopsyneuropathologyprogressive supranuclear palsysevere intellectual disability

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  • The spectrum of tauopathies, particularly four-repeat tauopathy, is not fully understood in the context of ID.