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Proteostasis regulation in T cell dysfunction: dual regulation by KLHL6

Yang Yu1, Jing Zhuang2, Changgang Sun2

  • 1Faculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.

Trends in Cell Biology
|April 9, 2026
PubMed
Summary

Kelch-like protein 6 (KLHL6) suppresses T cell exhaustion and mitochondrial dysfunction. This E3 ubiquitin ligase offers a new therapeutic target for enhancing cancer immunotherapy efficacy.

Keywords:
KLHL6T cell exhaustionmitochondrial dynamicsproteostasisubiquitination

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