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Biological Context and Endpoint Alignment Are Critical for Interpreting Population-Based Validation of Cluster-Based

Violeta Raverdy1, Guillemette Marot2, Guillaume Lassailly1

  • 1Inserm U1190, Lille University, CHU Lille, Lille, France.

Diabetes, Obesity & Metabolism
|April 10, 2026
PubMed
Abstract

No abstract available in PubMed .

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Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
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