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![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper-mediated photoinduced perfluoroalkylation of arylsulfonium salts
Yongfang Yang1, Lili Zhao1, Shengsheng Luo1
1School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi, 330031, China.
Abstract:
We herein report a copper-mediated, visible-light-promoted cross-coupling of aryl thianthrenium salts with [(DMPU)2Zn(Rf)2] reagents for site-selective late-stage perfluoroalkylation of arenes. The protocol displays a broad substrate scope and outstanding functional-group tolerance, accommodating diverse functional moieties, heterocyclic motifs, and complex drug-derived scaffolds. This approach markedly enriches the repertoire of late-stage perfluoroalkylation methods, providing a unified, modular, and chain-length-tunable platform for the construction of perfluoroalkylated compounds with potential applications in materials science, medicinal chemistry, and agrochemical development.
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