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Related Concept Videos

Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Related Experiment Video

Updated: Apr 11, 2026

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
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Circulating selectins as potential biomarkers for sarcopenia: a case-control study.

Hu Zhang1, Huaqing Liu2, Yanhui Tang1

  • 1Department of Endoscopy, Nanyang Central Hospital, Nanyang, Henan, China.

Frontiers in Medicine
|April 10, 2026
PubMed
Summary
This summary is machine-generated.

Elevated P-selectin levels are associated with sarcopenia in older adults. This finding suggests P-selectin may serve as a biomarker for muscle wasting and related health issues.

Keywords:
E-selectinL-selectinP-selectinbiomarkersolder adultssarcopenia

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Area of Science:

  • Gerontology
  • Biomarkers
  • Muscle Physiology

Background:

  • Sarcopenia, a condition characterized by age-related muscle loss, poses significant health challenges for older adults.
  • Understanding the underlying biological mechanisms, including inflammatory pathways, is crucial for developing effective interventions.

Purpose of the Study:

  • To investigate the association between circulating selectin levels (E-selectin, L-selectin, P-selectin) and sarcopenia in an older adult population.
  • To evaluate the diagnostic utility of P-selectin as a biomarker for sarcopenia.

Main Methods:

  • A case-control study involving 325 older adults (64 with sarcopenia, 261 controls) was conducted.
  • Sarcopenia diagnosis followed the Asian Working Group for Sarcopenia 2019 criteria.
  • Serum selectin concentrations were quantified using ELISA, with statistical analyses including ROC curve analysis and logistic regression.

Main Results:

  • Serum P-selectin levels were significantly higher in individuals with sarcopenia compared to controls (p < 0.001).
  • P-selectin demonstrated discriminative capacity for sarcopenia (AUROC = 0.693) with an optimal cutoff of 17.28 ng/mL.
  • Elevated P-selectin levels were independently associated with increased odds of sarcopenia, low appendicular muscle mass, and low handgrip strength.

Conclusions:

  • Circulating P-selectin is a novel and independent biomarker for sarcopenia in older adults.
  • Elevated P-selectin levels may indicate underlying endothelial activation and inflammatory processes contributing to muscle wasting.