Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iterative Multidisciplinary Development and Evaluation of a Patient-Facing SDoH Chatbot Using Synthetic Data Simulation.

JMIR formative research·2026
Same author

Comparison of survival outcomes for people with HR+/HER2- metastatic breast cancer who received palbociclib, ribociclib, or abemaciclib with an aromatase inhibitor: a plain language summary.

Future oncology (London, England)·2026
Same author

Treatment outcomes with palbociclib plus an aromatase inhibitor in patients with metastatic breast cancer who also have cardiovascular diseases: a plain language summary.

Future oncology (London, England)·2026
Same author

Bayesian generative modeling reveals a multi-modal hierarchical architecture in the mouse functional connectome.

bioRxiv : the preprint server for biology·2026
Same author

Mind the Performance Gap: Examining Dataset Shift During Prospective Validation.

Proceedings of machine learning research·2026
Same author

An Examination of Buprenorphine and Norbuprenorphine Concentrations in Inpatients Receiving Medications for Opioid Use Disorder.

The journal of applied laboratory medicine·2026
Same journal

Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene Interactions.

bioRxiv : the preprint server for biology·2026
Same journal

16S ribosomal RNA modification drives transcript-specific translation efficiency.

bioRxiv : the preprint server for biology·2026
Same journal

FlcE latches onto the FliL-stator complex to turbocharge flagellar motility in <i>Borrelia burgdorferi</i>.

bioRxiv : the preprint server for biology·2026
Same journal

Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence.

bioRxiv : the preprint server for biology·2026
Same journal

Structural and functional insights into the Rcs phosphorelay.

bioRxiv : the preprint server for biology·2026
Same journal

The structural basis of RanGAP1 regulation and catalysis in nuclear transport.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Apr 11, 2026

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.8K

Channel Capacity for Time-Resolved Effective Connectivity in Functional Neuroimaging.

Jianan Jian1, Benjamin Li2, Nurahmed Multezem3

  • 1Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.

Biorxiv : the Preprint Server for Biology
|April 10, 2026
PubMed
Summary
This summary is machine-generated.

We introduce information channel capacity to measure directed brain region interactions over time. This new method offers a scalable and interpretable way to understand dynamic brain connectivity across species.

Keywords:
causal modelingeffective connectivityfunctional brain dynamicsmultimodal neuroimaging

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.6K
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

6.2K

Related Experiment Videos

Last Updated: Apr 11, 2026

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

7.8K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.6K
Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology
09:44

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

6.2K

Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Computational Neuroscience

Background:

  • Understanding temporal brain region influence is key in neuroscience.
  • Current effective connectivity methods face challenges in interpretability, scalability, and time-resolved estimation.

Purpose of the Study:

  • Introduce information channel capacity (ICC) for measuring directed information transfer between brain regions.
  • Combine ICC with a sliding-window approach for time-varying directional interaction estimation.
  • Validate ICC across human and rodent neuroimaging datasets for sensitivity, specificity, and temporal variability.

Main Methods:

  • Utilized information channel capacity, a model-based measure of directed information transfer.
  • Employed a sliding-window framework to estimate dynamic directional interactions.
  • Validated the method using human fMRI, rat LFP-fMRI, and mouse Ca2+-fMRI datasets.

Main Results:

  • Human fMRI demonstrated ICC's sensitivity to task-related increases in directed interactions within motor regions.
  • Rat LFP-fMRI confirmed ICC's specificity, showing minimal spurious directional asymmetry.
  • Mouse Ca2+-fMRI revealed ICC's ability to identify reproducible dynamic connectivity states and transitions.

Conclusions:

  • Information channel capacity provides a physiologically grounded framework for dynamic directional interaction measurement.
  • The method is validated across species and neuroimaging modalities, overcoming limitations of existing approaches.
  • ICC enables robust, time-resolved analysis of brain network dynamics.