Related Experiment Video

Updated: Apr 11, 2026

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.9K

FOXK2 gene expression in cancer: Potential regulatory mechanisms and clinical implications

Renata Ivo Vasconcelos1, Luciana da Torre Carneiro1, Raquel Ciuvalschi Maia2

  • 1Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro (UFRJ), Avenida Carlos Chagas Filho, 373, 2° andar, H2-003, Cidade Universitária, Rio de Janeiro 21 941 599, Brazil.

Genes & Diseases
|April 10, 2026
PubMed

Insights

Aberrant FOXK2 expression impacts tumors. This review details FOXK2 gene expression, its diagnostic potential, and mechanisms of deregulation in cancer.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • FOXK2 is a transcription factor regulating cell fate.
  • Aberrant FOXK2 expression is observed in various tumors, impacting biology and clinical outcomes.
  • Mechanisms of FOXK2 gene deregulation in cancer remain largely unknown.

Purpose of the Study:

  • To systematically review FOXK2 gene expression across different tumor types.
  • To discuss the potential of FOXK2 as a prognostic and diagnostic molecular marker.
  • To explore emerging mechanisms of FOXK2 deregulation in cancer.

Main Methods:

  • Systematic review of FOXK2 gene expression profiles in distinct tumor types.
  • Analysis of genetic and transcriptional modifications contributing to FOXK2 deregulation.

Main Results:

  • FOXK2 exhibits altered expression patterns in various cancers.
  • FOXK2 shows potential as a diagnostic and prognostic marker.
  • Mechanisms including gene methylation, mutation, and copy number variations contribute to FOXK2 deregulation.

Conclusions:

  • Understanding FOXK2 deregulation is crucial for cancer research.
  • FOXK2 holds promise as a biomarker for cancer diagnosis and prognosis.
  • Further investigation into FOXK2's role can inform therapeutic strategies.
Keywords:
CancerClinical outcomesFOXK2 transcription factorGene alterationsTranscript expression

More Related Videos

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.3K
Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

997

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.2K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

3.1K
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.3K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K