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Orbital NUT carcinoma with intracranial extension
Ryan C Martin1, Mariah H Siddiqui1
1Department of Radiology, Loyola University Medical Center, 2160 S. First Avenue, Maywood, IL 60153, USA.
Radiology Case Reports
|April 10, 2026
Summary
Orbital NUT carcinoma, a rare cancer, can mimic infections and present challenges in diagnosis due to its unusual location and aggressive nature, requiring prompt multidisciplinary management.
Area of Science:
- Oncology
- Ophthalmology
- Pathology
Background:
- NUT carcinoma is a rare, aggressive cancer typically found in midline structures.
- Orbital involvement is uncommon and can be misdiagnosed as infection or inflammation.
- Chromosomal rearrangements of the NUTM1 gene drive NUT carcinoma.

