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Updated: Apr 11, 2026

Sample Drift Correction Following 4D Confocal Time-lapse Imaging
Published on: April 12, 2014
Data driven drift correction for complex optical systems
Aashwin Mishra1, Matthew Seaberg1, Ryan Roussel1
1SLAC National Laboratory, 2575 Sand Hill Rd, Menlo Park, CA 94025, USA.
Time varying Bayesian optimization (TVBO) offers robust drift correction for precise beam trajectories in complex experiments. This data-driven approach ensures stability in X-ray beam conditioning systems over extended durations.
Area of Science:
- Physics
- Experimental Physics
- Optical Engineering
Background:
- Modern light sources offer increased spectral brightness, enabling intricate experiments.
- Maintaining precise beam trajectory is crucial for these experiments.
- Active drift control is necessary to preserve beam stability over time.
Purpose of the Study:
- To introduce time varying Bayesian optimization (TVBO) as a data-driven method for robust drift correction.
- To demonstrate TVBO's application in a complex split and delay optical system.
- To showcase TVBO's adaptability for real-life experimental conditions.
Main Methods:
- Utilized numerical simulations to test TVBO.
- Applied TVBO to a system with six crystals and twelve input dimensions.
- Investigated TVBO for linear, non-smooth temporal drift, and constrained multi-objective control.
Main Results:
- TVBO demonstrated effective drift correction for various drift types.
- Constrained TVBO successfully handled multi-objective control settings.
- The approach proved robust under simulated real-life conditions.
Conclusions:
- TVBO is a powerful data-driven approach for maintaining beam stability.
- This method is adaptable to various X-ray beam conditioning and guidance systems.
- TVBO can ensure sub-micrometer and nanoradian beam stability for hours-long experiments.
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