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Updated: Apr 11, 2026

Sample Drift Correction Following 4D Confocal Time-lapse Imaging
Published on: April 12, 2014
Data driven drift correction for complex optical systems
Aashwin Mishra1, Matthew Seaberg1, Ryan Roussel1
1SLAC National Laboratory, 2575 Sand Hill Rd, Menlo Park, CA 94025, USA.
Abstract:
To exploit the thousand-fold increase in spectral brightness of modern light sources, increasingly intricate experiments are being conducted that demand extremely precise beam trajectory. Maintaining the optimal trajectory over several hours of an experiment with the needed precision necessitates active drift control. Here, we outline time varying Bayesian optimization (TVBO) as a data driven approach for robust drift correction, and illustrate its application for a split and delay optical system composed of six crystals and twelve input dimensions. Using numerical simulations, we exhibit the application of TVBO for linear drift, non-smooth temporal drift as well as constrained TVBO for multi-objective control settings, representing real-life operating conditions. This approach can be easily adapted to other X-ray beam conditioning and guidance systems, including multi-crystal monochromators and grazing-incidence mirrors, to maintain sub-micrometer and nanoradian beam stability over the course of an experiment spanning several hours.
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