Related Experiment Video
Updated: Apr 12, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Epigenetic age acceleration in diabetes and its clinical implications
Wajid Aslam Khan1, Jeena Gupta2
1Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Punjab, India.
None:
Epigenetic age acceleration (EAA), a discrepancy between biological and chronological age based on DNA methylation patterns, has emerged as a critical marker for aging and metabolic health. Individuals with diabetes, particularly type 2 diabetes (T2D), exhibit notable EAA, linking the disease to accelerated biological ageing. This review explores the mechanisms underlying EAA in diabetes, including hyperglycaemia-induced oxidative stress, inflammation, and dysregulated epigenetic pathways. Additionally, we discuss the clinical implications of EAA, emphasizing its potential as a biomarker for diabetes-related complications and a predictor of cardiovascular disease, nephropathy, and premature mortality. Emerging therapeutic strategies targeting epigenetic mechanisms, such as dietary interventions, pharmacological agents, and lifestyle modifications, are also reviewed. Understanding the interplay between EAA and diabetes opens avenues for personalized medicine and innovative treatments aimed at mitigating the accelerated aging phenotype associated with diabetes.
More Related Videos
06:21Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Related Concept Videos
Diabetes: Symptoms, Diagnosis, and Complications
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Type 2 and Gestational
Psychoneuroimmunology: Diabetes and Cancer
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...