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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
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Pathophysiological pathways in mild traumatic brain injury.

Mugdha Mohanty1, Alcy R Torres2

  • 1University of Massachusetts (UMASS), Worcester, MA, USA.

Seminars in Pediatric Neurology
|April 10, 2026
PubMed
Summary
This summary is machine-generated.

Mild traumatic brain injury (mTBI) involves complex brain dysfunction following trauma. This review details mTBI

Keywords:
TBITraumatic Brain InjurymTBI

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Area of Science:

  • Neuroscience
  • Traumatic Brain Injury Research
  • Pathophysiology

Background:

  • Mild traumatic brain injury (mTBI) is the most common brain injury, with diverse symptoms.
  • A subset of patients experience prolonged cognitive and somatic issues.
  • mTBI involves complex cellular and molecular cascades, including neuroinflammation and altered energy metabolism.

Purpose of the Study:

  • To review the key pathophysiological alterations in mTBI.
  • To discuss biomarkers and advanced imaging for mTBI detection.
  • To highlight permanent structural changes in mTBI.

Main Methods:

  • Literature review of mTBI pathophysiology.
  • Summary of cellular and molecular injury mechanisms.
  • Discussion of diagnostic tools for mTBI.

Main Results:

  • mTBI triggers a cascade of neurobiological events.
  • Energy supply-demand mismatch exacerbates brain injury.
  • Permanent structural brain changes can occur in mTBI.

Conclusions:

  • mTBI pathophysiology is complex, involving multiple molecular and cellular processes.
  • Advanced imaging and biomarkers are crucial for detecting mTBI, especially with persistent symptoms.
  • Understanding mTBI mechanisms is key to improving patient outcomes.