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AlphaFold3-based modeling uncovers the dynamic structural interface between full-length IAP antagonists and DIAP1 for

Pooja Rai1, Andreas Bergmann2

  • 1Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.

Cell Communication and Signaling : CCS
|April 10, 2026
PubMed
Abstract

No abstract available in PubMed .

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Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Keywords:
Drosophila ApoptosisAlphaFold3DIAP1IAP antagonistsProtein–protein interactionsReaperStructural modeling