Role of analytical chemistry in the development of magnetoliposomes: Current and emerging techniques

Magnetoliposomes are steadily moving to the forefront of nanomedomics as an advanced class of liposomes and lipid-based carriers. In recent years, considerable progress has been made in synthesizing and characterizing different magnetoliposomic structures, resulting in several attractive drug formulations with multimodal therapeutic and diagnostic functions. However, effective clinical translation remains difficult due to a lack of fundamental knowledge about the biological response to these nanohybrids. In this brief review, we explain our viewpoint on how this challenge can be addressed by using methods and approaches of analytical chemistry. Special focus is placed on the implementation and critical assessment of advanced analytical methodologies to investigate the magnetoliposome materials concerning their stability, drug loading efficiency, cellular internalization and processing (including external stimuli-responsive cargo release), biodistribution, etc.