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Updated: Apr 13, 2026

Silencing the Spark: CRISPR/Cas9 Genome Editing in Weakly Electric Fish
Published on: October 27, 2019
Science breaks silence
1ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai 200031, China; State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China; Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China.
Abstract:
In this Backstory, the author recounts treating a three-year-old with DFNB9 congenital deafness using inner-ear OTOF gene therapy. After counseling and careful surgical delivery of a dual-AAV vector, auditory brainstem responses became detectable and early speech followed. The story highlights multidisciplinary coordination, cautious interpretation of early outcomes, and the importance of longer-term outcome data.
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