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Neurodevelopment in Children Exposed to Antenatal CMV Viremia in a High HIV Prevalence Area

Ceri Evans1,2,3, Jaya Chandna1,4, Kuda Mutasa1

  • 1Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

The Journal of Infectious Diseases
|April 12, 2026
PubMed

We compared neurodevelopment at age 24 months among children born to mothers with or without cytomegalovirus (CMV) viremia in the third trimester of pregnancy in rural Zimbabwe, using the Malawi Developmental Assessment Tool (MDAT) for gross motor, fine motor, language and social development. Among 209 children, 49 (23%) were exposed to third-trimester CMV viremia. The mean total MDAT score was 91.0 (SD 9.4) in CMV-exposed children versus 94.1 (8.8) in CMV-unexposed children (adjusted difference -4.02 points [95% CI -7.01, -1.04, P = .008]). Cytomegalovirus exposure in utero, without evidence of congenital infection, may impair child neurodevelopment, providing a potential antenatal intervention target.

Keywords:
AfricaCMVHIV-exposed uninfectedco-infectionpregnancy

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