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Related Concept Videos

Assessment of the Mouth01:26

Assessment of the Mouth

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A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
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Updated: Apr 14, 2026

A Treatment Package without Escape Extinction to Address Food Selectivity
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Stepwise oral food challenge test.

Noriyuki Yanagida1, Sakura Sato, Motohiro Ebisawa

  • 1Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.

Current Opinion in Allergy and Clinical Immunology
|April 12, 2026
PubMed
Summary
This summary is machine-generated.

Stepwise oral food challenges (OFCs) using very-low-dose (VLD) or low-dose OFC are effective for diagnosing food allergies. This approach improves prognosis by avoiding complete food elimination and ensuring patient safety with appropriate dosing intervals.

Keywords:
cow's milk allergyfood allergylow doseoral food challengevery low dose

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Area of Science:

  • Allergy and Immunology
  • Clinical Pediatrics
  • Diagnostic Medicine

Background:

  • Oral food challenge (OFC) is the gold standard for diagnosing food allergies.
  • Stepwise OFC, initiating with very-low-dose (VLD) or low-dose OFC, is an emerging management strategy.

Purpose of the Study:

  • To critically evaluate the clinical utility of stepwise OFC.
  • To assess the safety profile of stepwise OFC approaches.

Main Methods:

  • Review of recent literature on stepwise OFC.
  • Analysis of VLD and low-dose OFC protocols and outcomes.

Main Results:

  • Stepwise OFC, beginning with VLD or low-dose OFC, is a critical diagnostic step.
  • VLD and low-dose OFCs are effective in preventing complete food elimination and enhancing prognosis.
  • An appropriate dosing interval of at least 1 hour is recommended for stepwise OFC safety.

Conclusions:

  • Stepwise OFCs utilizing VLD or low-dose OFC are effective and well-tolerated.
  • These methods aid in avoiding complete elimination of allergenic foods.
  • Stepwise OFC strategies can significantly improve the prognosis for children with food allergies.