Validation of the Olfato-UP olfactory test for the Brazilian population

To validate the Olfato-Up test in adults and elderly individuals from the Brazilian population.

The study was conducted in three stages. The first phase evaluated the population's familiarity with the chosen scents. The second phase assessed the performance of the Olfato-Up test, including sensitivity, specificity, accuracy, and cut-off determination. The third phase evaluated the test's reproducibility and the time required for its application.

All fragrances met the minimum accuracy requirements for the normosmic population. The cut-off score for anosmia and severe hyposmia was 7, with a sensitivity of 88.2%, specificity of 86.6%, accuracy of 86.7%, and an Area Under the Curve (AUC) of 90.7% for anosmia. For severe hyposmia, the sensitivity was 70.2%, specificity was 96%, accuracy was 89.8%, and the AUC was 90.1%. The Intraclass Correlation Coefficient (ICC) was 0.89. The Pearson correlation test revealed a correlation coefficient ofr = 0.811 (p = 0.001) and Bland-Altman test indicated a mean difference of -0.18 (95% CI -1.68 to 1.32). The average application time was 3.8 min (SD = 0.79).

Olfato-Up test demonstrated excellent reproducibility, a short application time, and high sensitivity, specificity, and accuracy for detecting anosmia and severe hyposmia.