Impact of Minimally Invasive Surgery on Systemic Immune Inflammation Index in Colorectal Cancer Patients

Area of Science:

• Surgical Oncology
• Immunology
• Biomarker Research

Background:

• Systemic inflammatory response impacts outcomes in colorectal cancer.
• Systemic Immune-Inflammation Index (SII) is a prognostic biomarker.
• Comparing surgical approaches' effect on SII is crucial for rectal cancer patients.

Purpose of the Study:

• To compare the postoperative systemic immune-inflammation index (SII) values between minimally invasive (robotic, laparoscopic) and open surgery for rectal cancer.
• To evaluate the impact of different surgical techniques on systemic inflammation post-rectal cancer surgery.

Main Methods:

• Retrospective analysis of 501 rectal cancer patients.
• Categorization into robotic, laparoscopic, and open surgery groups.
• Comparison of postoperative inflammatory markers including SII, NLR, and PLR.

Main Results:

• Open surgery patients showed significantly higher postoperative SII values (P = .004).
• Robotic surgery group exhibited significantly reduced postoperative SII values (P < .001).

Conclusions:

• Minimally invasive surgery, particularly robotic, significantly lowers postoperative systemic inflammation (SII) compared to open surgery.
• Lower SII in robotic surgery suggests reduced tissue trauma and better immune protection.
• SII serves as a practical, objective biomarker for assessing postoperative inflammation and surgical trauma in rectal cancer.