Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Consideration01:22

Design Consideration

642
Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
642
Experimental Designs01:16

Experimental Designs

18.6K
An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
18.6K
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

2.2K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
2.2K
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

26.3K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
26.3K
Design Example: Designing Water Slide01:18

Design Example: Designing Water Slide

754
When designing a water slide, controlling the speed of water flow is crucial for rider safety while maintaining an exciting experience. As water flows down the slide, gravity causes it to accelerate, with its speed at the bottom depending on the height from which it starts. The higher the slide, the more potential energy the water has at the top, which is converted into kinetic energy as it descends, increasing its speed.
Bernoulli's principle determines the water's velocity along the slide....
754
Design Example: Design of an Irrigation Channel01:27

Design Example: Design of an Irrigation Channel

1.2K
Trapezoidal channels are widely used in irrigation systems due to their cost-effectiveness and efficiency in conveying water. Trapezoidal channels feature a flat bottom and sloping sides, making them stable and easier to construct compared to other shapes. The bottom width and side slope ratio are determined based on the required flow capacity and site conditions. The side slope is kept gentle for unlined channels to prevent soil erosion.Hydraulic parameters in channel design include the flow...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and Translational Science Award hubs in learning health systems: evaluation framework of the engine-drivetrain model.

Journal of translational medicine·2026
Same author

Clinical and translational science award hubs in learning health systems: development of the engine-drivetrain model.

Journal of translational medicine·2026
Same author

Toward an effective translational science engine.

Clinical and translational science·2024
Same author

Area under the inspiratory flow-volume curve (AIN): Proposed normative values.

PloS one·2024
Same author

Obstructive sleep apnoea, oxygen desaturation and hypoxic burden: pebble, rock or boulder?

Respirology (Carlton, Vic.)·2024
Same author

Assessing obstructive sleep apnoea by oxygen desaturation metrics: Pre-dawn clearing.

Respirology (Carlton, Vic.)·2024
Same journal

EXPRESS: Association between composite lipid indices (AIP, VAI, LAP) and Carotid Atherosclerosis with plaque: a Systematic review and Meta-analysis.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2026
Same journal

Meta-analysis of the clinical efficacy of microcatheter-assisted trabeculotomy in the treatment of glaucoma.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2026
Same journal

EXPRESS: The Association of Hidradenitis Suppurativa with Increased Risk of Systemic Infections in End-stage Renal Disease.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2026
Same journal

Artificial intelligence perceptions and experiences among first and second year medical students.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2026
Same journal

Effects of the glucagon-like peptide-1 and glucagon receptor dual agonists on glycemic markers: A systematic review and meta-analysis of randomized controlled trials.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2026
Same journal

EXPRESS: Enhancing clinical core competencies in postgraduate medical education: a comparative study of augmented reality-assisted and traditional teaching approaches.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2026
See all related articles

Related Experiment Video

Updated: Apr 14, 2026

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

17.3K

A functional design model for research, development, and discovery: Innovation orchards.

Octavian C Ioachimescu1

  • 1Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|April 13, 2026
PubMed
Summary
This summary is machine-generated.

Biomedical research translation from lab to population involves complex, costly stages. An innovation orchard framework can accelerate discovery adoption through adaptable research and development ecosystems.

Keywords:
biomedical researchinnovationresearchresearch designtranslational medical researchtranslational science

More Related Videos

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

830
Building an Enhanced Flight Mill for the Study of Tethered Insect Flight
12:09

Building an Enhanced Flight Mill for the Study of Tethered Insect Flight

Published on: March 10, 2021

3.7K

Related Experiment Videos

Last Updated: Apr 14, 2026

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
20:24

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

Published on: January 31, 2014

17.3K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

830
Building an Enhanced Flight Mill for the Study of Tethered Insect Flight
12:09

Building an Enhanced Flight Mill for the Study of Tethered Insect Flight

Published on: March 10, 2021

3.7K

Area of Science:

  • Biomedical research
  • Translational science
  • Innovation ecosystems

Background:

  • The biomedical discovery pathway from laboratory research to population-level impact is complex, lengthy, and costly.
  • This translational spectrum involves distinct stages, from inception (T0) to population health (T5).
  • Effective innovation ecosystems are crucial for accelerating the adoption of scientific discoveries.

Purpose of the Study:

  • To describe the challenges and stages of the biomedical discovery journey.
  • To propose an innovation orchard framework for accelerating research translation.
  • To highlight the need for adaptable research and development hubs.

Main Methods:

  • Conceptual framework development based on the translational spectrum.
  • Analysis of innovation processes within academic and organizational settings.
  • Metaphorical application of 'innovation trees' and 'orchards' to describe research ecosystems.

Main Results:

  • The translational journey is characterized by iterative cycles, trade-offs, and significant time/cost investments.
  • Existing research and development hubs may require 'engineered' or 'hybrid' approaches to bridge capability gaps.
  • An 'innovation orchard' framework can regulate and foster the growth of diverse innovation types.

Conclusions:

  • Implementing an innovation orchard framework can enhance agile functionality in translating research to clinical care and population health.
  • Adaptable ecosystems are essential for efficiently adopting incremental and breakthrough discoveries.
  • This framework supports the complete discovery journey, from ideation to broad societal impact.