Synergistically Enhanced Composite Hemostatic Material Derived from Crinis Carbonisatus and Sepiolite

Area of Science:

• Biomaterials Science
• Materials Engineering
• Biomedical Engineering

Background:

• Developing effective hemostatic materials is crucial for managing bleeding.
• Natural materials offer potential for low-cost, biocompatible hemostatic solutions.
• Combining different natural components can lead to synergistic improvements in material performance.

Purpose of the Study:

• To fabricate and characterize Crinis Carbonisatus-Sepiolite (Cri-Sep) composites.
• To investigate the synergistic hemostatic mechanism and performance of these composites.
• To provide a novel strategy for designing natural mineral-carbon composite hemostatic materials.

Main Methods:

• Solid-state reaction was used to synthesize Cri-Sep composites.
• Experimental analysis, including blood viscoelasticity tests, was performed.
• Coagulation function parameters were detected to assess hemostatic activity.

Main Results:

• Cri-Sep composites exhibited enhanced hemostatic properties compared to single components.
• Blood storage modulus increased rapidly, indicating improved viscoelasticity.
• Coagulation time was significantly reduced, and both extrinsic and intrinsic pathways were activated.

Conclusions:

• The Cri-Sep composite demonstrates a synergistic hemostatic mechanism.
• The material's structure facilitates both high surface area and bioactive site integration.
• This study presents a promising strategy for clinical translation of natural hemostatic materials.