Study Protocol: Protocol of Intensive Care Unit Graded Mobilization (PG-Motion) Study: A Randomized Clinical Trial

Area of Science:

• Critical care medicine
• Rehabilitation therapy
• Clinical trial methodology

Background:

• Intensive care unit-acquired weakness (ICU-AW) is a common complication in critically ill patients.
• Early mobilization (EM) improves outcomes but faces implementation barriers, especially in China due to staffing and protocol limitations.
• A nurse-led EM protocol tailored to Chinese ICUs is needed to address these challenges.

Purpose of the Study:

• To develop and evaluate a nurse-led EM protocol (PG-Motion Study) for Chinese ICUs.
• To assess the clinical effectiveness of this tailored EM protocol in preventing ICU-AW.
• To provide an evidence-based framework for EM in resource-constrained critical care settings.

Main Methods:

• A multicentre randomized controlled trial (RCT) involving 18 Grade III hospitals in Beijing, China.
• Individual randomization (1:1) to either the PG-Motion guided EM protocol or standard care.
• Primary outcomes include ICU-AW incidence (MRC sum score < 48), mechanical ventilation duration, and ICU length of stay; safety monitored for adverse events.

Main Results:

• The PG-Motion protocol is expected to establish an evidence-based mobilization framework suitable for Chinese ICU staffing.
• Findings may inform national consensus and promote standardized EM practices for ICU-AW prevention.
• The study will generate evidence for a scalable, nurse-led EM protocol.

Conclusions:

• The PG-Motion study aims to provide clinical and operational evidence for a nurse-led EM protocol.
• This protocol has the potential to enhance early rehabilitation in resource-limited Chinese ICUs.
• The findings may support the widespread adoption of EM for ICU-AW prevention.