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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Related Experiment Video

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Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
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Kidney Failure in Persons With Cystic Fibrosis.

Mirjana Stevanovic1, Todd A MacKenzie2, Asha M Zimmerman3

  • 1Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Kidney Medicine
|April 13, 2026
PubMed
Summary
This summary is machine-generated.

People with cystic fibrosis (PwCF) have a significantly higher prevalence of kidney failure. While diabetes is a less frequent cause, lung transplant complications are a major factor in PwCF kidney failure.

Keywords:
CFRDCystic fibrosiscomplications of lung transplantcystic fibrosis-related diabetesdiabeteskidney failurelung transplant

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Area of Science:

  • Nephrology
  • Pulmonology
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is more common in people with cystic fibrosis (PwCF).
  • CKD can lead to kidney failure, necessitating dialysis or transplantation.
  • Understanding kidney failure in PwCF is crucial for managing their health outcomes.

Purpose of the Study:

  • To determine the prevalence of kidney failure in PwCF.
  • To characterize the causes and outcomes of kidney failure in PwCF.
  • To compare kidney failure in PwCF with the general population without CF.

Main Methods:

  • Retrospective cohort study utilizing US Renal Data System (USRDS) data from 2014-2018.
  • Analysis included demographic characteristics, causes of kidney failure, transplant status, mortality, and survival.
  • Statistical methods included regression, propensity score-matched Kaplan-Meier curves, and log-rank tests.

Main Results:

  • Kidney failure prevalence was 22.6-29.3 times greater in PwCF compared to the general US population.
  • Diabetes was a less frequent primary cause of kidney failure in PwCF (24.3%) versus non-CF individuals (42.3%).
  • Complications from lung transplantation were a significantly more frequent cause in PwCF (16.9%) than in non-CF individuals (0.03%).

Conclusions:

  • PwCF exhibit a substantially higher prevalence of kidney failure.
  • The etiology of kidney failure in PwCF differs, with lung transplant complications being a major driver.
  • Median survival for kidney failure patients was similar between PwCF and matched non-CF individuals.