Related Experiment Video
Updated: Apr 14, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Contrast-enhanced Perfusion Measurements in Patients with Active Crohn's Disease Using Sonazoid
Kim Nylund1,2, Fredrik Sævik3, Odd Helge Gilja1,2
1National Center of Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway.
Purpose:
This study aimed to assess the feasibility of dynamic contrast-enhanced ultrasound with Sonazoid, its correlation with disease activity, its ability to differentiate between remission/mild activity and moderate/severe activity, and if a region of interest including the mucosa and submucosa was different compared to one encompassing the entire wall.
Materials And Methods:
We prospectively studied 48 patients with Crohn's disease who underwent colonoscopy and dynamic contrast-enhanced ultrasound with Sonazoid from 2015 to 2019. We compared the local simple endoscopic score for Crohn's disease in the most affected area with parameters from Vuebox, including peak enhancement, wash-in and wash-out area under the curves, wash-in and wash-out rates, and wash-in perfusion index. Region of interest-1 (ROI-1) included all wall layers, and region of interest-2 (ROI-2) included the mucosa and submucosa. Linear data and normalised data were used. Technical failure or a quality of fit value of<80% was considered a failed examination.
Results:
The feasibility of the dynamic contrast-enhanced ultrasound examination was 73%. No significant findings were noted in the linear data ( p >0.05). In the normalised data in both ROI-1 and ROI-2, the local simple endoscopic score for Crohn's disease correlated significantly with peak enhancement ( r =0.38 and r =0.35), wash-in rate ( r =0.34 and r =0.34), and wash-in perfusion index ( r =0.40 and r =0.37) and with wash-in area under the curve ( r =0.36) in ROI-2. In patients with moderate/severe disease peak enhancement, wash-in area under the curve, wash-out area under the curve, wash-in rate, and wash-in perfusion index were significantly higher in both region of interests ( p <0.05). All parameters were significantly different in ROI-1 and ROI-2 ( p <0.05).
Conclusions:
Dynamic contrast-enhanced ultrasound parameters can differentiate between remission/mild and moderate/severe activity in Crohn's disease, but the method has relatively low feasibility.
Related Concept Videos
01:17Assessment of Diffusion and Perfusion
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
01:09Methods for Studying Drug Absorption: In situ
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
01:20Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...