Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

6.4K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
6.4K
¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons01:03

¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons

5.2K
Protons in identical electronic environments within a molecule are chemically equivalent and have the same chemical shift. The replacement test is a useful tool to identify chemical equivalence and predict NMR spectra. A substituent replaces each of the protons being examined and the resulting molecules are compared. If the same molecule is obtained, the protons are equivalent or homotopic. Replacement of any hydrogens in ethane by chlorine yields chloroethane because all six protons are...
5.2K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

6.1K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling.

Frontiers in neuroscience·2019
Same author

Enzyme characterization and biological activities of a resuscitation promoting factor from an oil degrading bacterium <i>Rhodococcus erythropolis</i> KB1.

PeerJ·2019
Same author

MXene Boosted CoNi-ZIF-67 as Highly Efficient Electrocatalysts for Oxygen Evolution.

Nanomaterials (Basel, Switzerland)·2019
Same author

A Biomimetic Hierarchical Nanointerface Orchestrates Macrophage Polarization and Mesenchymal Stem Cell Recruitment To Promote Endogenous Bone Regeneration.

ACS nano·2019
Same author

Adjacent intact nociceptive neurons drive the acute outburst of pain following peripheral axotomy.

Scientific reports·2019
Same author

Daily intake of soft drinks is associated with symptoms of anxiety and depression in Chinese adolescents.

Public health nutrition·2019

Related Experiment Video

Updated: Apr 14, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

1.6K

Differences in iron content between gray matter heterotopia and normal gray matter.

Dan Luo1,2, Zexiang Deng1,2, Xinru Deng1,2

  • 1Department of Radiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.

Quantitative Imaging in Medicine and Surgery
|April 13, 2026
PubMed
Summary

This study found lower iron levels in gray matter heterotopia (GMH) compared to normal gray matter (NGM) using enhanced T2*-weighted magnetic resonance angiography (ESWAN). These findings suggest altered iron deposition may contribute to GMH-related epilepsy.

Keywords:
Enhanced T2*-weighted magnetic resonance angiography (ESWAN)epilepsygray matter heterotopia (GMH)

More Related Videos

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

4.7K
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.8K

Related Experiment Videos

Last Updated: Apr 14, 2026

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

1.6K
A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

4.7K
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.8K

Area of Science:

  • Neuroscience
  • Radiology
  • Epileptology

Background:

  • Gray matter heterotopia (GMH) is a frequent cause of epilepsy, but its underlying mechanisms are not fully understood.
  • Iron deposition is a suspected factor influencing neuronal excitability in epilepsy.
  • This study investigates iron deposition differences in GMH to clarify GMH-related epilepsy pathophysiology.

Purpose of the Study:

  • To quantitatively assess iron deposition differences between GMH and normal gray matter (NGM).
  • To explore the role of iron deposition in the pathophysiology of GMH-related epilepsy.

Main Methods:

  • Utilized enhanced T2*-weighted magnetic resonance angiography (ESWAN) for quantitative iron assessment.
  • Enrolled 78 patients with 105 GMH lesions, acquiring phase and magnitude images.
  • Compared quantitative parameters between GMH and ipsilateral NGM using paired sample t-tests.

Main Results:

  • Significantly lower phase values were observed in GMH compared to NGM in both right (P=0.028) and left (P=0.002) hemispheres.
  • Magnitude values were also significantly lower in GMH (right: P=0.003; left: P=0.013) compared to NGM.
  • Periventricular nodular heterotopia was the most common type of GMH observed.

Conclusions:

  • ESWAN imaging effectively revealed differences in iron deposition between GMH and NGM.
  • Altered iron deposition in GMH may play a role in the development of epilepsy.