[The regional network for CAR-T therapies in the Lazio Region: a governance model for innovation and sustainability.]

The CAR-T therapies are characterized by high clinical, organizational, and economic complexity, requiring the adoption of dedicated governance models capable of ensuring equitable access, appropriateness, and sustainability. In this context, the Lazio Region has developed a regional network for the management of CAR-T therapies based on a multidisciplinary steering committee, a network of hospital centers, an informative platform, and a system for planning needs and assessing appropriateness. The system is based on the Real-World Data and a Horizon Scanning approach for the continuous updating of therapeutic indications. This experience represents an example of sustainable and replicable governance for the management of advanced therapies at the regional level.