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Updated: Apr 14, 2026

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
Published on: February 15, 2019
Democratizing the Cure: Indigenous Innovations and the Future of Pediatric Cell and Gene Therapy in India
Prasad Iyer1,2, Rajat Bhattacharyya3, Gaurav Kharya4,5
1Children's Blood and Cancer Centre, KK Women's and Children's Hospital, Singapore, Singapore. drprasad_iyer@yahoo.co.uk.
Abstract:
Cell and gene therapy (CGT) represents a paradigm shift in the treatment of diseases once regarded incurable. This is particularly true for pediatric cancers and inherited disorders which often have a monogenic basis. While the global landscape of CGT is rapidly evolving with numerous approved products, India faces unique challenges in adopting high-cost, complex therapies. This perspective offers a comprehensive overview of the current status of pediatric CGT in India, emphasizing the urgent need for affordable and indigenous alternatives. We examined the spectrum of conditions for which CGT shows potential for pediatric patients, analyzed significant research and clinical studies from India, and investigated the pipeline of new products and therapies approaching clinical trials. This analysis provides a roadmap for the future of this transformative field in India in light of emerging regulatory and ethical regulations.
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