Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

5.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.2K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

4.2K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.2K
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

3.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.3K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

4.2K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.2K
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

2.0K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
2.0K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

2.2K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of ephrin-B2 loaded glycol chitosan-silk fibroin hydrogel in the treatment of diabetic refractory wounds.

Scientific reports·2026
Same author

Corrigendum to "Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation" [Cancer Lett. (2018) 10 429 1-10.doi: 10.1016/j.canlet.2018.04.041.Epub 2018 May 5].

Cancer letters·2026
Same author

Effects of remote transitional care on stroke patients: a meta-analysis.

Frontiers in neurology·2026
Same author

Biomimetic MXene nanoplatform for tumor-specific synergistic phototherapy and immune reprogramming in pancreatic cancer.

Biomaterials science·2026
Same author

Therapeutic effects of hemoperfusion in treating long-acting anticoagulant rodenticide poisoning.

Blood purification·2026
Same author

The dual role of the CXCL9/10/11-CXCR3 axis in the tumor immune microenvironment: Mechanisms, therapeutic implications, and clinical translation.

Pharmacological research·2026
Same journal

Acute lung injury and progressive pulmonary fibrosis following chlorotrifluoroethylene inhalation: insights from a case.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Suspected serotonin toxicity following combined nefopam and tramadol use in an older adult.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Serum benzylpenicillin levels during treatment for amatoxin poisoning: pharmacokinetic support for OATP1B3 inhibition.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Unlabeled kratom alkaloids detected in products marketed as kava.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Contemporary survey of United States poison center treatment recommendations for sodium channel blocking drug poisoning.

Clinical toxicology (Philadelphia, Pa.)·2026
Same journal

Safety of acetylcysteine: a scoping review of iatrogenic overdose cases and their associated complications.

Clinical toxicology (Philadelphia, Pa.)·2026
See all related articles

Related Experiment Video

Updated: Apr 14, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

21.2K

Diffuse endobronchial polyposis associated with chlorosilane inhalation.

Chengcheng Ji1, Lili Bai1, Xiaobo Peng1

  • 1Department of Poisoning Treatment, Senior Department of Hematology, the Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China.

Clinical Toxicology (Philadelphia, Pa.)
|April 13, 2026
PubMed
Summary
This summary is machine-generated.

Chlorosilane inhalation can cause severe lung damage and difficulty weaning from mechanical ventilation. A rare complication includes diffuse endobronchial polyps, requiring interventional bronchoscopy for treatment.

Keywords:
Bronchoscopychlorosilaneendobronchial polyposisinhalation toxicityradiography

More Related Videos

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

1.4K
A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
10:45

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust

Published on: January 6, 2023

3.1K

Related Experiment Videos

Last Updated: Apr 14, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

21.2K
Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

1.4K
A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
10:45

A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust

Published on: January 6, 2023

3.1K

Area of Science:

  • Occupational Medicine
  • Pulmonology
  • Toxicology

Background:

  • Chlorosilane is a common industrial chemical with unclear human health effects.
  • Acute lung injury from chemical inhalation is a significant concern in occupational settings.

Purpose of the Study:

  • To report a case of severe lung damage and endobronchial polyposis following chlorosilane inhalation.
  • To highlight the potential long-term respiratory sequelae of chlorosilane exposure.

Main Methods:

  • Case report of a 57-year-old male with accidental chlorosilane inhalation.
  • Utilized serial radiography and bronchoscopy to assess respiratory injury and polyp formation.
  • Interventional bronchoscopy performed for polyp removal.

Main Results:

  • The patient developed severe lung damage, refractory CO2 retention, and difficulty weaning.
  • Bronchoscopy revealed diffuse endobronchial polyposis two months post-exposure.
  • Radiographs and bronchoscopy images documented the progression of respiratory injury and polyp development.

Conclusions:

  • Chlorosilane inhalation can lead to severe, acute lung injury.
  • Diffuse endobronchial polyps are an uncommon but significant sequela, potentially causing prolonged respiratory compromise and weaning difficulties.
  • Management may involve interventional bronchoscopy, with careful consideration of corticosteroid risks.