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Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Steps in Outbreak Investigation01:18

Steps in Outbreak Investigation

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In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
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Updated: Apr 15, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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From Exposure to Disease: Predicting Tuberculosis Progression.

Mariana Araújo-Pereira1,2, Rajita Bhavaraju3, Mark Hatherill4

  • 1Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|April 13, 2026
PubMed
Summary
This summary is machine-generated.

Identifying individuals at high risk of active tuberculosis (TB) remains a challenge. This review synthesizes research, focusing on RePORT studies, to improve targeted TB prevention and elimination strategies.

Keywords:
disease progressioninfectionlatentpredictiontuberculosis

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Area of Science:

  • Infectious Diseases
  • Public Health
  • Genetics

Background:

  • Tuberculosis (TB) affects a quarter of the global population, with 5-10% developing active disease.
  • Current diagnostic tools lack precision in identifying individuals at highest risk of active TB progression.
  • Close contacts of TB cases face a significantly elevated risk.

Purpose of the Study:

  • To review current knowledge on TB transmission, biomarkers, and genetic factors.
  • To evaluate predictive models for identifying high-risk individuals.
  • To discuss implications for public health interventions and screening programs.

Main Methods:

  • Synthesis of current knowledge on TB transmission dynamics.
  • Analysis of biomarkers and genetic factors influencing disease progression.
  • Review of predictive models and findings from RePORT International studies.

Main Results:

  • Existing approaches have limitations, including temporal dynamics and context dependence of host-response signatures.
  • RePORT studies provide insights into diverse populations and large-scale data.
  • Challenges for implementation in high-burden settings are identified.

Conclusions:

  • Refining targeted TB prevention strategies is crucial for TB elimination.
  • Improved identification of high-risk individuals can enhance public health interventions.
  • Further research is needed to address implementation challenges in high-burden settings.