Pediatric Pleomorphic Xanthoastrocytomas: A Multicenter Neuroradiological and Clinical Correlation Study

Karanjot Chhatwal1, Thomas Hargreaves1, Francesco Pacchiano1

  • 1From the Imperial College School of Medicine (K.C.), Imperial College London, London, UK; Department of Radiology (K.C., T.H., H.M., P.S., F.D., U.L., U.G., S.S., A.B., K.M.), Department of Neurosurgery (K.A.), Department of Histopathology (T.S.J., A. M.), Great Ormond Street Hospital for Children, Great Ormond Street, London; Barts and The London School of Medicine and Dentistry (T.H.), Queen Mary University of London, London, UK; University of Naples (F.P.), Federico II, Naples, Italy; Department of Radiology (C.A., V.R.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts; Children's Healthcare of Atlanta (A.E.G.- Y.), Emory University School of Medicine, GA, USA; Department of Radiology (A.B., A.K., A.G.), Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Radiology (A.J., K.W.Y.), Phoenix Children's Hospital, Phoenix, AZ, USA; Department of Radiology (J.N.), Seattle Children's Hospital, Seattle, WA, USA; Department of Neuroscience (E.P.), Imaging and Clinical Sciences, University of Chieti-Pescara, Chieti, Italy; Oncological Neuroradiology and Advanced Diagnostics Unit (E.P.), Bambino Gesùu Children's Hospital, IRCCS, Rome, Italy; Department of Radiology (K.H., K.A.), Aga Khan University Hospital, Karachi, Pakistan and UCL GOS Institute of Child Health (T.S.J.), London, UK.

Summary

This study reveals that pediatric pleomorphic xanthoastrocytomas (PXAs) have specific imaging and molecular traits linked to outcomes. Early surgical removal of pediatric brain tumors improves survival, guiding personalized treatment strategies.