[Research Progress on the Role and Mechanisms of PYCR1 
in Tumorigenesis and Progression]

Pyrroline-5-carboxylate reductase 1 (PYCR1) is a key enzyme in the proline biosynthesis pathway and has garnered widespread attention in the field of tumor research in recent years. Studies have shown that PYCR1 is abnormally expressed in a variety of malignant tumors. It plays a significant role in tumorigenesis and development by participating in metabolic reprogramming of tumor cells, regulating key signaling pathways, influencing the tumor microenvironment, and mediating immune evasion, among other mechanisms. This article systematically reviews the biological structure and functions of PYCR1, its expression characteristics in various tumors, and the underlying molecular mechanisms. The focus is on exploring its role in promoting the occurrence and development of different tumors, as well as its involvement in mediating chemotherapy resistance. Additionally, the research progress and clinical application prospects of PYCR1 as a potential therapeutic target are analyzed, providing a theoretical basis and research directions for the development of novel anti-tumor strategies.
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