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Updated: Apr 15, 2026

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Marginal Eyeliner Use and Meibomian Gland Function.

Mariam Alkawally1, Rachelle J Lin2, Corina van de Pol3

  • 1Independent Researcher, Calgary, AB T2V 4J2, Canada.

Journal of Clinical Medicine
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

Chronic eyeliner use on the eyelid margin worsens ocular staining and meibomian gland function. This cosmetic practice can lead to decreased gland excretion quality, potentially causing long-term damage.

Keywords:
eyelinermakeupmeibomian gland excretameiboscore

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Cosmetic Science

Background:

  • Chronic use of cosmetics, particularly near the eyelid margin, is common.
  • Potential links between cosmetic use and ocular surface health remain under investigation.

Purpose of the Study:

  • To investigate the impact of chronic cosmetic use on the eyelid margin.
  • To determine if cosmetic use contributes to tear film instability and meibomian gland dysfunction.

Main Methods:

  • Three groups of subjects were assessed: rarely wear makeup (No-M), frequent wear outside the margin (Min-M), and frequent wear on the margin (W-M).
  • Evaluations included tear film assessments (lipid layer thickness, tear meniscus height, tear breakup time), meibomian gland evaluation (excreta grade, number secreting), and ocular surface staining.
  • A masked examiner assessed dry eye signs and symptoms.

Main Results:

  • Eyeliner use on the eyelid margin (W-M group) showed significantly higher grades for meibomian gland excreta compared to non-users.
  • Increased ocular staining (corneal and conjunctival) and poorer meibomian gland secretions were observed in the W-M group.
  • No significant differences were found in lipid layer thickness, tear breakup time, or meibomian gland dropout among groups.

Conclusions:

  • Eyeliner application on the eyelid margin is associated with increased ocular surface staining.
  • This practice leads to decreased quality of meibomian gland secretions.
  • Reduced meibomian gland excretion may impair meibomian gland function and potentially lead to glandular atrophy over time.