Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

518
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
518
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

765
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
765

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of Chronic Kidney Disease Based on Simulated Serum Analysis by Vibrational Spectroscopy.

Biosensors·2026
Same author

Pre-Transplant Serum FTIRS Signatures as Predictive Biomarkers of Early Transient Pancreatic Graft Dysfunction in Simultaneous Pancreas-Kidney Transplantation.

Life (Basel, Switzerland)·2026
Same author

Blood biomarker trajectories in ICU-directed prediction models - A scoping review.

The EPMA journal·2026
Same author

Coffee consumption and chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Molecular epidemiology and surveillance of imported dengue in travellers returning to Spain, 2022-2024.

Travel medicine and infectious disease·2026
Same author

Rejection-Focused Precision Medicine in Kidney Transplantation: Biology, Biomarkers, and Artificial Intelligence.

Life (Basel, Switzerland)·2026
Same journal

Evidence-Based Clinical Recommendations for the Appropriate Use of Diagnostic Tests in Pediatric Allergology: Focus on Asthma, Rhinoconjunctivitis, and Keratoconjunctivitis Vernal.

Journal of clinical medicine·2026
Same journal

Surgical and Transcatheter Approach of a Failed Mitral Valve Repair: A Comprehensive Review on Selecting the Most Suitable Approach.

Journal of clinical medicine·2026
Same journal

Hybrid Metaheuristic Feature Selection for Breast Cancer Detection in Digital Mammography: A Feasibility Study with Nested Validation, Benchmarking, and External Stress Testing.

Journal of clinical medicine·2026
Same journal

Identity Transformation and the Role of Accountability in Recovery from Problematic Pornography Use: A Phenomenological-Hermeneutical Study.

Journal of clinical medicine·2026
Same journal

Does Early Surgical Treatment in Degenerative Cervical Myelopathy Have a Favorable Clinical Outcome and Impact on Quality of Life?

Journal of clinical medicine·2026
Same journal

Shear Wave Elastography in Musculoskeletal Imaging: A Narrative Review.

Journal of clinical medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 15, 2026

Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.7K

Machine Learning-Assisted FTIR Spectroscopy Analysis of Kidney Preservation Fluids for Delayed Graft Function Risk

Luis Ramalhete1,2,3,4, Rúben Araújo2, Miguel Bigotte Vieira2,3,5

  • 1Blood and Transplantation Center of Lisbon, Instituto Português do Sangue e da Transplantação, Alameda das Linhas de Torres, n◦ 117, 1769-001 Lisbon, Portugal.

Journal of Clinical Medicine
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

Fourier transform infrared (FTIR) spectroscopy of kidney preservation fluid shows promise for predicting delayed graft function (DGF) after transplantation. This technique may enhance early risk stratification for DGF, complementing existing clinical predictors.

Keywords:
FTIR spectroscopycalibrationdecision curve analysisdelayed graft functiondonor-blinded validationfingerprint regionkidney transplantationmachine learningpreservation fluid

More Related Videos

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.9K
High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
11:05

High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology

Published on: January 21, 2015

34.1K

Related Experiment Videos

Last Updated: Apr 15, 2026

Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.7K
Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.9K
High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
11:05

High-definition Fourier Transform Infrared FT-IR Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology

Published on: January 21, 2015

34.1K

Area of Science:

  • Nephrology
  • Biochemistry
  • Spectroscopy

Background:

  • Delayed graft function (DGF) is a common post-transplant complication that is difficult to predict using standard clinical factors.
  • Current methods for anticipating DGF before implantation are insufficient.

Purpose of the Study:

  • To evaluate if Fourier transform infrared (FTIR) spectroscopy of static cold storage preservation fluid can identify biochemical markers associated with DGF.
  • To assess the utility of FTIR spectroscopy alongside traditional clinical predictors for DGF risk stratification.

Main Methods:

  • A retrospective analysis of preservation fluid from 56 deceased donor kidney transplants was conducted.
  • High-throughput FTIR spectroscopy was used to analyze the fluid's biochemical composition.
  • Predictive models (clinical-only, FTIR-only, combined) were developed and validated using donor-blinded cross-validation.

Main Results:

  • The FTIR-only model achieved a higher area under the receiver operating characteristic curve (0.814) compared to the clinical-only model (0.775).
  • The combined model showed a discrimination of 0.796, indicating potential for improved DGF prediction.
  • Decision curve analysis supported the clinical utility of FTIR-based risk stratification at certain thresholds.

Conclusions:

  • FTIR spectroscopy of preservation fluid is a feasible, low-cost method for exploratory DGF risk stratification.
  • This technique shows potential as a supplementary tool to improve early DGF prediction.
  • Further validation in larger, multicenter cohorts and prospective studies are necessary before clinical deployment.