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Updated: Apr 15, 2026
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Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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Chronic Kidney Disease and Cellular Senescence.
Marya Morevati1, Juliette Tavenier2, Morten Scheibye-Knudsen3
1Department of Nephrology and Endocrinology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.
International Journal of Molecular Sciences
|April 14, 2026
Summary
Cellular senescence, a key factor in kidney aging, drives chronic kidney disease (CKD) progression through inflammation and fibrosis. Senotherapeutic strategies and AI are emerging as promising interventions for CKD.
Area of Science:
- Nephrology
- Gerontology
- Cellular Biology
Background:
- Chronic kidney disease (CKD) and kidney aging share pathological similarities.
- Cellular senescence, characterized by the senescence-associated secretory phenotype (SASP), contributes to kidney inflammation and fibrosis.
- Accumulation of senescent cells in the kidney is driven by persistent stressors.
Purpose of the Study:
- To review the intersection of CKD and renal aging.
- To explore mechanisms of senescence in the kidney.
- To discuss senotherapeutic interventions and AI/ML applications in senescence detection.
Main Methods:
- Literature review focusing on cellular senescence in CKD and kidney aging.
- Exploration of senotherapeutic approaches (senolytics, senomorphics, rejuvenating agents).
- Discussion of artificial intelligence (AI) and machine learning (ML) in senescence monitoring.
Main Results:
- Cellular senescence is a significant contributor to CKD progression and renal aging.
- SASP exacerbates kidney damage through chronic inflammation and fibrosis.
- AI and ML offer advanced tools for high-throughput detection and monitoring of senescent cells.
Conclusions:
- Targeting cellular senescence presents a novel therapeutic strategy for CKD.
- Senolytics, senomorphics, and rejuvenating agents show potential for slowing CKD progression.
- AI and ML integration can enhance the precision and efficiency of senescence assessment in clinical and experimental settings.
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