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Open and closed-loop control systems01:17

Open and closed-loop control systems

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Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
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Feedback control systems are categorized in various ways based on their design, analysis, and signal types.
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
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Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
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Controller Configurations01:22

Controller Configurations

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Controller configurations are crucial in a car's cruise control system because they manage speed over time to maintain a consistent pace regardless of road conditions, thereby meeting design goals. In traditional control systems, fixed-configuration design involves predetermined controller placement. System performance modifications are known as compensation.
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Updated: Apr 15, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists
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Monitoring Inputs, Control Architectures, and Failure Modes in Closed-Loop Vasopressor Systems: A Comprehensive

Vitor Felippe1, Hiorrana Sousa Dias2, Carlos Darcy Alves Bersot3,4

  • 1Department of Anesthesiology, National Cancer Institute (INCA), Rio de Janeiro 20230-130, RJ, Brazil.

Sensors (Basel, Switzerland)
|April 14, 2026
PubMed
Summary
This summary is machine-generated.

Closed-loop vasopressor systems use real-time monitoring for hemodynamic stability. This review details their architectures, sensor impacts, and reliability issues, proposing future validation priorities.

Keywords:
automationclosed-loop controlfailure modeshemodynamic monitoringperioperative technologyreliabilitysignal integrityvasopressor

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Area of Science:

  • Biomedical Engineering
  • Critical Care Medicine
  • Automation and Control Systems

Background:

  • Closed-loop vasopressor systems are crucial for hemodynamic stability in critical care.
  • These systems rely on real-time monitoring, signal processing, and automated decision-making.
  • Sensor quality and system integration directly impact performance and safety.

Purpose of the Study:

  • To comprehensively review closed-loop vasopressor system architectures.
  • To analyze the influence of sensor modality and signal integrity on algorithm behavior.
  • To identify reliability vulnerabilities and propose future research directions.

Main Methods:

  • Literature synthesis of major closed-loop vasopressor architectures.
  • Examination of sensor impacts on control logic and system performance.
  • Analysis of reliability vulnerabilities across the information pipeline (monitoring to actuation).

Main Results:

  • Identified common performance metrics for control quality benchmarking.
  • Summarized recurrent reliability vulnerabilities in sensors, control logic, and integration.
  • Highlighted clinical validation patterns and evidence gaps for high-risk populations.

Conclusions:

  • Emphasized the need for sensor robustness, transparent algorithm design, and integration safeguards.
  • Proposed standardized documentation of failures and overrides for future studies.
  • Stressed practical considerations for clinical deployment and validation in diverse settings.