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Monocyte Transmigration Involves in Remifentanil Induced Mechanical Hyperalgesia in Animal Models and a Randomized

Rui Zhang1, Zexi Ye1, Qianru Chen1

  • 1Department of Anesthesiology, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, People's Republic of China.

Journal of Pain Research
|April 14, 2026
PubMed
Summary

Monocyte transmigration drives remifentanil-induced hyperalgesia (RIH). Flurbiprofen axetil mitigates RIH by retaining monocytes and modulating chemokine signals, offering a targeted therapeutic strategy for pain management.

Keywords:
hyperalgesiamonocytesnon−steroidal anti−inflammatory drugsremifentanil

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