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Single-Cell Profiling Reveals Distinct Immune Communication Networks in Centenarians and Elderly Controls

Liwei Qiu1, Chen Dong1, Rui Zhao1

  • 1Research Center of Clinical Medicine, Research Center of Gerontology and Longevity, Research Center of Immunology, Department of Rheumatology, Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong University, Nantong, China.

Aging Cell
|April 14, 2026
PubMed
Summary

Healthy aging involves distinct immune cell-cell communication (CCC) patterns. Centenarians and their offspring show enhanced immune signaling, unlike controls exhibiting immunosenescence, offering insights into exceptional longevity.

Keywords:
centenarianimmune communication networksimmune remodelingsingle‐cell transcriptomesuccessful aging

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