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Updated: Apr 15, 2026

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Rheumatoid Factor Interference in Dual Immunoassays: False-Positive Procalcitonin and CK-MB Results.
Clinical Laboratory
|April 14, 2026
Summary
High rheumatoid factor (RF) levels can cause falsely elevated procalcitonin (PCT) and CK-MB immunoassay results. Testing on alternative platforms and using RF blocking agents can help correct these interferences and prevent misdiagnosis.
Area of Science:
- Clinical Chemistry
- Immunology
- Laboratory Medicine
Background:
- Immunoassays for procalcitonin (PCT) and CK-MB are vital for diagnosing sepsis and myocardial injury.
- Rheumatoid factor (RF), an autoantibody, can cause false positives in sandwich immunoassays by bridging antibodies.
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