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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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A Collaborative Initiative to Improve Anaphylaxis Management in Utah Schools.

Bryan S Witt1,2, Benjamin L Wright2,3

  • 1Mayo Clinic Alix School of Medicine, Scottsdale, Arizona.

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|April 14, 2026
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Summary
This summary is machine-generated.

Food allergies can be life-threatening. Training school staff to recognize and respond to anaphylaxis (a severe allergic reaction) improves emergency response and ensures epinephrine is administered promptly, protecting students.

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Area of Science:

  • Public Health
  • Allergy & Immunology
  • Pediatric Education

Background:

  • Food allergies pose a significant public health risk, with fatalities often linked to delayed epinephrine administration.
  • Utah schools faced challenges in managing food allergy emergencies due to insufficient school nurses and trained personnel.
  • A standardized approach to food allergy emergency management was lacking in Utah schools.

Purpose of the Study:

  • To develop and implement a web-based curriculum for training school staff on recognizing and responding to anaphylaxis.
  • To educate school officials about legal protections for layperson epinephrine responders.
  • To facilitate the procurement of epinephrine for schools via charitable programs.

Main Methods:

  • A web-based anaphylaxis training curriculum was developed and implemented.
  • Educational outreach was conducted for school officials regarding legal protections.
  • Partnerships were formed to acquire unassigned epinephrine for school use.

Main Results:

  • The training program was completed 5,759 times by staff from 421 Utah schools between 2012 and 2023.
  • Teachers, office staff, and principals were the most frequent participants in the training.
  • There was a 245% increase in schools stocking unassigned epinephrine, and retention rates exceeded 68% since 2015.

Conclusions:

  • The intervention successfully increased the number of Utah schools prepared to administer epinephrine during anaphylactic emergencies.
  • Training school staff, including non-nursing personnel, is crucial for timely anaphylaxis response.
  • Expanding training to volunteers is recommended to further reduce treatment delays and improve student outcomes in schools.