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Licorice extract (LE) effectively repairs acute uranium damage by influencing key metabolic pathways. This study utilized metabolomics to reveal LE's restorative mechanisms, highlighting its potential in traditional Chinese medicine.

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acute uranium injurybreath sampling devicegas chromatography–mass spectrometryglycyrrhizic acidmetabolomics

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Area of Science:

  • Toxicology
  • Metabolomics
  • Traditional Chinese Medicine

Background:

  • Licorice (Gancao) is a traditional antidote known for detoxification.
  • Glycyrrhizic acid (GL) from licorice promotes uranium excretion and mitigates uranium damage.
  • The precise mechanisms of licorice's protective effects against uranium injury are not fully understood.

Purpose of the Study:

  • To investigate the reparative effects of licorice extract (LE) on acute uranium injury using a metabolomics approach.
  • To elucidate the underlying mechanisms of LE's therapeutic action against uranium toxicity.
  • To identify key metabolic pathways involved in the amelioration of uranium damage by LE.

Main Methods:

  • A metabolomics approach combining respiratory analysis and gas chromatography-mass spectrometry (GC-MS) was employed.
  • High-performance liquid chromatography (HPLC) was used to quantify glycyrrhizic acid content in licorice.
  • Rat models of acute uranium injury were treated with LE for 7 days, followed by breath and serum sample analysis.

Main Results:

  • LE administration led to significant recovery in rat body weight and peripheral blood parameters.
  • Breath metabolomics identified 8 differentially expressed metabolites, and serum metabolomics identified 17 associated with uranium injury.
  • Metabolic pathway analysis revealed LE's restorative effects via 4 respiratory and 5 serum key pathways, with glycine, serine, and threonine metabolism showing the strongest association.

Conclusions:

  • Licorice extract (LE) effectively ameliorates acute uranium damage.
  • Metabolomics provides a powerful tool for understanding the therapeutic mechanisms of traditional Chinese medicine (TCM) in treating acute uranium injury.
  • Glycine, serine, and threonine metabolism are critical pathways targeted by LE for uranium damage repair.