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Updated: Apr 16, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Can a Lipid-Containing Co-Processed Excipient Overcome Compression Challenges Associated with a Cohesive and

Ivana Aleksić1, Teodora Glišić2, Slobodanka Ćirin-Varađan2

  • 1Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade, 11000, Serbia. ivana.aleksic@pharmacy.bg.ac.rs.

AAPS Pharmscitech
|April 14, 2026
PubMed
Summary

A novel lipid-containing co-processed excipient significantly improves acetaminophen powder flowability and tablet mechanical properties. This excipient demonstrates superior performance over RetaLac® in overcoming API processing challenges.

Keywords:
co-processingcompactibilitycompression characterizationparacetamoltabletability

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