Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.8K
1.8K
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

127
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
127
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

141
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
141
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.4K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Force-Locking DNA Hairpin Probes for High-Throughput and Cumulative Detection of Intercellular Molecular Tensions.

Angewandte Chemie (International ed. in English)·2026
Same author

Mismatch-Driven CRISPR/Cas12a Biosensing of UV-Induced DNA Lesions for Environmental Solar Exposure Surveillance.

Environmental science & technology·2026
Same author

Programmable and Switchable RNA Scaffolds for Synthetic Condensate Engineering in Mammalian Cells.

bioRxiv : the preprint server for biology·2026
Same author

Sensitive Detection of Intercellular Tensile Forces via Cas12a-Assisted Membrane Molecular Probes.

Nano letters·2025
Same author

Method for Imaging and Quantifying Molecular Tensions at Cell-Cell Junctions Using DNA-Based Fluorescent Probes.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Force-Responsive Delivery of Anticancer Drugs via a DNA Mechanical Nanovehicle.

Nano letters·2024

Related Experiment Video

Updated: Apr 16, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Mechanically Triggered DNA Nanovehicles for Targeted Dual-Drug Cancer Therapy.

Murali Mohana Rao Singuru1, Priyanka Bhattacharyya1, Mingxu You1,2

  • 1Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 15, 2026
PubMed
Summary

Scientists developed a novel DNA nanovehicle for dual-drug delivery. This force-responsive system releases anticancer drugs in response to mechanical stress, enabling targeted cancer therapy with reduced side effects.

Keywords:
DNA nanovehicledual‐drug deliveryintegrin‐mediated forcesintercellular forcestargeted cancer therapy

More Related Videos

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.2K
Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
11:52

Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors

Published on: June 18, 2013

11.6K

Related Experiment Videos

Last Updated: Apr 16, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K
Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

8.2K
Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
11:52

Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors

Published on: June 18, 2013

11.6K

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Drug Delivery Systems

Background:

  • Mechanical dysregulation is implicated in various diseases, but force-responsive drug delivery platforms are scarce.
  • Stimuli-responsive dual-drug delivery systems offer precise therapeutic control and enhanced synergy.
  • Current systems often lack specificity, leading to off-target effects and increased dosage.

Purpose of the Study:

  • To develop a DNA-based nanovehicle capable of dual-drug release in response to mechanical forces.
  • To investigate the selective activation and efficacy of this mechanoresponsive system in cancer cells.
  • To establish a new class of targeted cancer therapies with improved safety and effectiveness.

Main Methods:

  • Constructed cholesterol-modified DNA nanovehicles for anchoring to cell membranes.
  • Engineered constructs to undergo force-induced structural changes for drug release.
  • Utilized tensile forces generated by integrin receptors at cell-cell junctions for activation.
  • Evaluated drug release and cytotoxicity in HeLa, MCF-7, and HEK293T cell lines.

Main Results:

  • Demonstrated selective drug release in response to mechanical tension in cancer cells (HeLa, MCF-7).
  • Achieved potent cytotoxicity against cancer cells while minimizing effects in low-tension cells (HEK293T).
  • Successfully integrated mechanosensing, force visualization, and targeted dual-drug delivery (TMPyP4 and doxorubicin).

Conclusions:

  • Introduced a novel DNA-based mechanoresponsive nanovehicle for dual-drug delivery.
  • This platform enables targeted cancer therapy by responding to mechanical cues at cell-cell junctions.
  • The system offers a promising approach for safer and more effective cancer treatments by enhancing selectivity and reducing side effects.