Densiron 68 Tamponade Duration and Redetachment Risk after Removal in Inferior Proliferative...

Area of Science:

• Ophthalmology
• Retinal Surgery
• Vitreoretinal Interface

Background:

• Inferior retinal detachment (I-RD) with proliferative vitreoretinopathy (PVR) presents treatment challenges and high recurrence rates.
• Heavy silicone oil (HSO) tamponades like Densiron-68 are utilized for I-RD management.
• The protective effect of prolonged Densiron-68 tamponade against recurrence after oil removal requires investigation, particularly in patients with prior failed surgeries.

Purpose of the Study:

• To evaluate if prolonged Densiron-68 tamponade (≥3 months) reduces recurrence of I-RD after HSO removal.
• To assess the impact of prolonged tamponade on recurrence in patients with and without a history of failed retinal detachment surgery.

Main Methods:

• Retrospective review of 112 eyes with rhegmatogenous I-RD and PVR treated with pars plana vitrectomy and Densiron-68.
• Multivariate logistic regression analysis was performed.
• Patients were stratified based on history of failed RD surgery and tamponade duration (short <3 months vs. long ≥3 months).

Main Results:

• Overall, prolonged Densiron-68 tamponade did not significantly reduce recurrence rates (RDR) after oil removal (OR 1.02; p=0.867).
• Eyes with a history of failed RD surgery had significantly higher odds of RDR (OR 4.44; p=0.0028).
• In the subgroup with prior failed surgery, prolonged tamponade was associated with lower recurrence rates compared to short tamponade (OR 3.96; p=0.025).

Conclusions:

• Prolonged Densiron-68 tamponade does not offer overall protection against RDR after oil removal.
• Extended tamponade duration may be beneficial for patients with a history of failed RD surgery.
• Routine prolongation of HSO tamponade appears unnecessary for lower-risk patients; further prospective studies are needed.