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Updated: Apr 17, 2026

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
Published on: April 7, 2023
From bench to gut: Translational horizons in probiotic nanoencapsulation for enhanced host-microbiome synergy
Khushbu1, Sumistha Das1, Nitai Debanth1
1Amity Institute of Biotechnology, Amity University Haryana, Gurugram, 122413, India.
Abstract:
Delivering viable probiotics to the gastrointestinal tract remains a challenge due to harsh physicochemical conditions and limited stability during processing and storage. Conventional microencapsulation techniques, such as spray drying, lyophilization, and emulsification, enhance survival but face scalability and efficiency constraints. Emerging nanostructured delivery platforms overcome these barriers by leveraging unique physicochemical properties of nanomaterials, including high surface area, enhanced solubility, and stimuli-responsive release. Functionalized nanocarriers enable site-specific adhesion, systemic delivery, and prolonged mucosal residence, thereby enhancing therapeutic precision and reducing off-target effects. This article highlights the potential of co-encapsulating probiotics with microbial metabolites, prebiotic carbohydrates, and polyphenolic compounds within biopolymeric matrices, which can significantly enhance translational applications and strengthen conventional probiotic nanoencapsulation strategies. This review consolidates current advancements in probiotic nanoencapsulation, emphasizing the design of multifunctional matrices that preserve microbial integrity, extend shelf life, and optimize host-microbiome interactions. By elucidating nanoparticle-probiotic interfacial dynamics, it lays the groundwork for next-generation probiotic therapeutics with improved efficacy and translational potential.
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