Related Experiment Video
Updated: Apr 17, 2026
Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
Long-term outcomes in adults born preterm with symptomatic patent ductus arteriosus
Alysha Joseph1,2, Alvin Chandra1, Gregory P Barton1
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Objective:
To compare outcomes in young adults born prematurely with and without symptomatic patent ductus arteriosus (PDA) during infancy.
Study Design:
Young adults born preterm (≤32 weeks gestation; n = 107) were recruited from the Parkland Health Neonatal Intensive Care Unit (NICU) Registry and compared based on presence of symptomatic PDA during their NICU stay (n = 23 with PDA), defined as clinical evidence of large left-to-right shunt or congestive heart failure.
Results:
Systolic blood pressure was similar, but the PDA group exhibited higher resting diastolic blood pressure (80 ± 10 versus 74 ± 12 mmHg, p = 0.02). Biventricular systolic function was similar. However, tissue Doppler imaging (TDI) velocities at the lateral/septal aspect of the mitral annulus were lower and RV end-diastolic diameter larger in the PDA group.
Conclusions:
Individuals born preterm with a symptomatic PDA exhibited elevated diastolic blood pressure, slightly lower diastolic function, and larger right ventricular size in early adulthood.
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