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Cyclophosphamide alters gut microbiota metabolism and structure in lymphoma-bearing mice: implications for dietary

Shufang Fan1,2, Jiawei Yao1,2, Liyun Yang1,2

  • 1Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, China.

Irish Journal of Medical Science
|April 15, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
CyclophosphamideGut microbiotaInulinMetabolic functionTumor-bearing mice

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The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
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The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
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