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CSF ctDNA Molecular Clearance as a Prognostic Biomarker for Orelabrutinib-Treated Primary Central Nervous System
Lixia Sheng1, Huijie Hu2, Yanli Lai1
1Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Abstract:
This prospective biomarker study evaluated serial CSF ctDNA monitoring in newly diagnosed PCNSL treated with R-MO induction therapy. Mid-treatment ctDNA clearance was significantly associated with complete response and superior progression-free survival, showing stronger predictive value than interim PET-CT in this cohort. These findings support CSF ctDNA clearance as a promising molecular biomarker for early response assessment in PCNSL.
