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Related Experiment Video

Updated: May 5, 2026

Author Spotlight: Nuclei Isolation from Mouse Cardiac Progenitor Cells for Epigenome and Gene Expression Profiling at Single-Cell Resolution

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Lineage-Specific Sex-Biased Transcriptional Programs in Healthy Human Truncal Skin Revealed by Single-Cell

Yu Yang^1,2, Honghao Yu², Binbin Lai^1,2

¹Institute of Medical Technology, Peking University Health Science Center, Beijing 100191, China.

|May 4, 2026

Summary

Healthy human skin shows sex differences in gene expression, not cell types. Male skin favors extracellular matrix and immune genes, while female skin favors ion transport and neuromodulation, impacting skin health and disease.

Keywords:

sex-biased gene expression sexual dimorphism single-cell RNA sequencing skin truncal skin

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Area of Science:

Human skin biology
Transcriptomics
Sex differences research

Background:

Sex influences skin physiology, immunity, and disease.
Cellular basis of sex-biased gene expression in skin is not fully understood.

Purpose of the Study:

Define sex-associated differences in cellular composition and gene expression.
Analyze healthy adult human truncal skin at single-cell resolution.

Main Methods:

Constructed a sex-resolved single-cell transcriptomic atlas from 12 donors.
Classified 107,967 cells into 14 major cell types.
Assessed sex-associated differences using pseudo-bulk analyses.

Main Results:

Cellular composition was similar between sexes, with differences in mast cells and regulatory T cells.
Identified distinct male-biased (extracellular matrix, immune response) and female-biased (ion transport, neuromodulation) transcriptional programs.
Most sex-biased genes were lineage-specific.

Conclusions:

Sexual dimorphism in skin is driven by lineage-specific transcriptional regulation.
Provides a framework for understanding sex-biased skin homeostasis.
Informs research on sex-specific skin disease susceptibility.