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Electrochemical Methylarene Oxidation via Electrolyte Anion Control: Access to 18O-Labeled Aromatic Aldehydes
Ziyue Xu1, Shiyu Lei1, Lesi Xu1
1Department of Chemistry, Nanchang University, Nanchang, 330031, P. R. China.
Abstract:
The electrochemical oxidation of methylarenes to aromatic aldehydes has been extensively studied. Nevertheless, strategies capable of efficiently oxidizing both electron-rich and electron-deficient methylarenes remain scarce. Herein, we report a method that utilizes water as the oxygen source, enabling the selective oxidation of both types of methylarenes to aldehydes by modulation of the electrolyte anions. The reaction shows remarkable regioselectivity for polymethyl-substituted arenes, producing only mono-oxidized products. Importantly, 18O-labeled aldehydes were successfully synthesized via this method with high 18O incorporation.
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