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Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

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[Development Status and Evaluation Strategy Considerations on In Vitro Alternative Methods for Skin Sensitization

Likui Sun¹, Xiaoxia Sun¹, Xiaofei Wang¹

¹Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection, Jinan, 250101.

Zhongguo Yi Liao Qi Xie Za Zhi = Chinese Journal of Medical Instrumentation

|April 16, 2026

Summary

The study explores in vitro and genomic methods for medical device skin sensitization testing, aligning with animal welfare advancements. These alternative approaches are crucial for the future of medical device biological evaluation.

Area of Science:

Toxicology
Biocompatibility Testing
Dermatology

Keywords:

alternative method evaluation strategy medical device tests for skin sensitization

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